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Vision Research Foundation

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+91-44-42271500


Dr Sailaja Elchuri, PhD

Associate Professor
Department of Nanobiotechnology



Got PhD from University of Hyderabad, under a distinguished plant Physiologist. Prof V.S. Rama Das in 1995. Post-Doctoral Studies at Arizona State University (1998-1999). Post-Doctoral Fellow at University of California at San Francisco (Department of Pediatric Genetics) (200-2004) and Stanford University (Department of Neurology) Research Scientist (Department of Immunology and Microbiology) (2005-2009. Joined Vision Research Foundation in 2011.

Research interest includes molecular progression of tumorigenesis in Pediatric tumours and targeted therapy in eye tumours specially Retinoblastoma.Making nanoscaffolds for 3D cancer cell growth for rapid drug screening and therapy

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  1. Selvan LDN, Danda R, Madugundu AK, Puttamallesh VN, Sathe GJ, Krishnan UM,Khetan V, Rishi P, Prasad TSK, Pandey A, Krishnakumar S, Gowda H, Elchuri SV.Phosphoproteomics of Retinoblastoma: A Pilot Study Identifies Aberrant Kinases.Molecules. 2018 Jun 15;23(6). pii: E1454. doi: 10.3390/molecules23061454. PubMed PMID: 29914080.

  2. Elchuri SV, Rajasekaran S, Miles WO. RNA-Sequencing of Primary Retinoblastoma Tumors Provides New Insights and Challenges Into Tumor Development. Front Genet. 2018 May 17;9:170. doi: 10.3389/fgene.2018.00170. eCollection 2018. PubMed PMID: 29868118; PubMed Central PMCID: PMC5966869.

  3. Danda R, Ganapathy K, Sathe G, Madugundu AK, Krishnan UM, Khetan V, Rishi P,Gowda H, Pandey A, Subramanian K, Prasad TSK, Elchuri SV. Membrane Proteome ofInvasive Retinoblastoma: Differential Proteins and Biomarkers. Proteomics ClinAppl. 2018 Sep;12(5):e1700101. doi: 10.1002/prca.201700101. Epub 2018 Jun 13.PubMed PMID: 29742327.

  4. Kalmodia S, Parameswaran S, Ganapathy K, Yang W, Barrow CJ, Kanwar JR, Roy K, Vasudevan M, Kulkarni K, Elchuri SV, Krishnakumar S. Characterization and Molecular Mechanism of Peptide-Conjugated Gold Nanoparticle Inhibiting p53-HDM2Interaction in Retinoblastoma. MolTher Nucleic Acids. 2017 Dec 15;9:349-364.doi: 10.1016/j.omtn.2017.10.012. Epub 2017 Oct 20. PubMed PMID: 29246314; PubMed Central PMCID: PMC5684491.

  5. Danda R, Ganapathy K, Sathe G, Madugundu AK, Ramachandran S, Krishnan UM,Khetan V, Rishi P, Keshava Prasad TS, Pandey A, Krishnakumar S, Gowda H, Elchuri SV. Proteomic profiling of retinoblastoma by high resolution mass spectrometry.Clin Proteomics. 2016 Oct 26;13:29. eCollection 2016. PubMed PMID: 27799869;PubMed Central PMCID: PMC5080735.

  6. Jayashree B, Srimany A, Jayaraman S, Bhutra A, Janakiraman N, Chitipothu S,Krishnakumar S, Baddireddi LS, Elchuri S, Pradeep T. Monitoring of changes in lipid profiles during PLK1 knockdown in cancer cells using DESI MS. Anal Bioanal Chem. 2016 Aug;408(20):5623-32. doi: 10.1007/s00216-016-9665-y. Epub 2016 Jun 8. PubMed PMID: 27277815.

  7. Kalmodia S, Vandhana S, Tejaswini Rama BR, Jayashree B, Sreenivasan Seethalakshmi T, Umashankar V, Yang W, Barrow CJ, Krishnakumar S, Elchuri SV.Bio-conjugation of antioxidant peptide on surface-modified gold nanoparticles: a novel approach to enhance the radical scavenging property in cancer cell. Cancer Nanotechnol. 2016;7:1. doi: 10.1186/s12645-016-0013-x. Epub 2016 Feb 9. PubMedPMID: 26900409; PubMed Central PMCID: PMC4747989.

  8. Elchuri SV, Govindjee. VallabhaneniSita Rama Das, 1933-2010: teacher and mentor. Photosynth Res. 2016 May;128(2):109-15. doi: 10.1007/s11120-015-0210-1.Epub 2015 Dec 16. PubMed PMID: 26676024.

  9. Srimany A, Jayashree B, Krishnakumar S, Elchuri S, Pradeep T. Identification of effective substrates for the direct analysis of lipids from cell lines usingdesorption electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom.2015 Feb 28;29(4):349-56. doi: 10.1002/rcm.7111. PubMed PMID:26406347.

  10. Beta M, Krishnakumar S, Elchuri SV, Salim B, Narayanan J. A comparative fluorescent beacon-based method for serum microRNA quantification. Anal Sci.2015;31(3):231-5. doi: 10.2116/analsci.31.231. PubMed PMID: 25765279.

  11. Danda R, Krishnan G, Ganapathy K, Krishnan UM, Vikas K, Elchuri S, ChatterjeeN, Krishnakumar S. Targeted expression of suicide gene by tissue-specificpromoter and microRNA regulation for cancer gene therapy. PLoS One. 2013 Dec31;8(12):e83398. doi: 10.1371/journal.pone.0083398. eCollection 2013. PubMedPMID: 24391761; PubMed Central PMCID: PMC3877029.

  12. Kalmodia S, Harjwani J, Rajeswari R, Yang W, Barrow CJ, Ramaprabhu S,Krishnakumar S, Elchuri SV. Synthesis and characterization of surface-enhancedRaman-scattered gold nanoparticles. Int J Nanomedicine. 2013;8:4327-38. doi:10.2147/IJN.S49447. Epub 2013 Nov 6. PubMed PMID: 24235830; PubMed Central PMCID:PMC3826772.

  13. Subramanian N, Raghunathan V, Kanwar JR, Kanwar RK, Elchuri SV, Khetan V,Krishnakumar S. Target-specific delivery of doxorubicin to retinoblastoma usingepithelial cell adhesion molecule aptamer. Mol Vis. 2012;18:2783-95. Epub 2012Nov 22. PubMed PMID: 23213278; PubMed Central PMCID: PMC3513190

  14. Kode K, Shachaf C, Elchuri S, Nolan G, Paik DS. Raman Labeled Nanoparticles: Characterization of Variability and Improved Method for Unmixing. J RamanSpectrosc. 2012 Jul 1;43(7):895-905. PubMed PMID: 24833814; PubMed Central PMCID:PMC4019428.

  15. Shachaf CM, Elchuri SV, Koh AL, Zhu J, Nguyen LN, Mitchell DJ, Zhang J,Swartz KB, Sun L, Chan S, Sinclair R, Nolan GP. A novel method for detection ofphosphorylation in single cells by surface enhanced Raman scattering (SERS) usingcomposite organic-inorganic nanoparticles (COINs). PLoS One. 2009;4(4):e5206.doi: 10.1371/journal.pone.0005206. Epub 2009 Apr 15. PubMed PMID: 19367337;PubMed Central PMCID: PMC2666268.

  16. Koh AL, Shachaf CM, Elchuri S, Nolan GP, Sinclair R. Electron microscopy localization and characterization of functionalized composite organic-inorganicSERS nanoparticles on leukemia cells. Ultramicroscopy. 2008 Dec;109(1):111-21.doi: 10.1016/j.ultramic.2008.09.004. Epub 2008 Oct 2. PubMed PMID: 18995965;PubMed Central PMCID: PMC2650478.

  17. Shachaf CM, Gentles AJ, Elchuri S, Sahoo D, Soen Y, Sharpe O, Perez OD, ChangM, Mitchel D, Robinson WH, Dill D, Nolan GP, Plevritis SK, Felsher DW. Genomicand proteomic analysis reveals a threshold level of MYC required for tumormaintenance. Cancer Res. 2008 Jul 1;68(13):5132-42. doi:10.1158/0008-5472.CAN-07-6192. PubMed PMID: 18593912; PubMed Central PMCID:PMC4191850.

  18. Shachaf CM, Perez OD, Youssef S, Fan AC, Elchuri S, Goldstein MJ, Shirer AE, Sharpe O, Chen J, Mitchell DJ, Chang M, Nolan GP, Steinman L, FelsherDW.Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis. Blood. 2007 Oct 1;110(7):2674-84. Epub 2007 Jul 10. PubMed PMID:17622571; PubMed Central PMCID: PMC1988916.

  19. Elchuri S, Naeemuddin M, Sharpe O, Robinson WH, Huang TT. Identification ofbiomarkers associated with the development of hepatocellular carcinoma in CuZnsuperoxide dismutase deficient mice. Proteomics. 2007 Jun;7(12):2121-9. PubMedPMID: 17514684; PubMed Central PMCID: PMC2729784.

  20. Erker L, Schubert R, Elchuri S, Huang TT, Tarin D, Mueller K, Zielen S,Epstein CJ, Wynshaw-Boris A. Effect of the reduction of superoxide dismutase 1and 2 or treatment with alpha-tocopherol on tumorigenesis in Atm-deficient mice. Free RadicBiol Med. 2006 Aug 15;41(4):590-600. Epub 2006 May 10. PubMed PMID:16863992.

  21. Huang TT, Naeemuddin M, Elchuri S, Yamaguchi M, Kozy HM, Carlson EJ, Epstein CJ. Genetic modifiers of the phenotype of mice deficient in mitochondrialsuperoxide dismutase. Hum Mol Genet. 2006 Apr 1;15(7):1187-94. Epub 2006 Feb 23. PubMed PMID: 16497723.

  22. Lynn S, Huang EJ, Elchuri S, Naeemuddin M, Nishinaka Y, Yodoi J, FerrieroDM,Epstein CJ, Huang TT. Selective neuronal vulnerability and inadequate stressresponse in superoxide dismutase mutant mice. Free RadicBiol Med. 2005 Mar15;38(6):817-28. PubMed PMID: 15721992.

  23. Elchuri S, Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, Epstein CJ, Huang TT. CuZnSOD deficiency leads to persistent and widespreadoxidative damage and hepatocarcinogenesis later in life. Oncogene. 2005 Jan13;24(3):367-80. PubMed PMID: 15531919.

  24. Limoli CL, Rola R, Giedzinski E, Mantha S, Huang TT, Fike JR.Cell-density-dependent regulation of neural precursor cell function. ProcNatlAcadSci U S A. 2004 Nov 9;101(45):16052-7. Epub 2004 Nov 2. PubMed PMID:15522966; PubMed Central PMCID: PMC528770.

  25. Huang, T.T., Mantha, S. and Epstein, C.J., 2003. in the Pathogenesis of Down Syndrome. Redox-Genome Interactions in Health and Disease, p.409.

  26. Huang TT, Carlson EJ, Kozy HM, Mantha S, Goodman SI, Ursell PC, Epstein CJ.Genetic modification of prenatal lethality and dilated cardiomyopathy in Mnsuperoxide dismutase mutant mice. Free RadicBiol Med. 2001 Nov 1;31(9):1101-10. PubMed PMID: 11677043.

Selected Publications from Plant Sciences

Mantha, S.V., Johnson, G.A. and Day, T.A., 2001. Evidence from Action and Fluorescence Spectra that UV‐Induced Violet–Blue–Green Fluorescence Enhances Leaf Photosynthesis. Photochemistry and photobiology, 73(3), pp.249-256.

Sailaja, M.V. and Das, V.R., 2000. Differential photosynthetic acclimation pattern to limiting growth-irradiance in two types of C 4 plants. Photosynthetica, 38(2), pp.267-273.

Mantha, S.V., Karunasri, K. and Subrahmanyam, N.C., 2000. In vitro spectrofluorometric determination of chlorophyll de novo synthesis in chlorophyll-deficient phenotypes of Pennisetumglaucum (L.) R. Br. Canadian Journal of Botany, 78(6), pp.798-806.

Sailaja, M.V. and Das, V.R., 1996. Leaf solar tracking response exhibits diurnal constancy in photosystem II efficiency. Environmental and Experimental Botany, 36(4), pp.431-438.

developed leaves of Amaranthushypochondriacus L., an NAD-ME C4 plant.Photosynth Res. 1995 Nov;46(1-2):227-33. doi: 10.1007/BF00020435. PubMed PMID:24301587.

1987
Prime Minister of India Award from academic excellence in 1987.

Net qualified and ARS qualified.

Reviewer for Several Journals



Ms Lakshmi B
PhD student



Mr Ranjith Kumar R



Ms Lakshmi B
PhD student



Mr Ranjith Kumar R

Dr Sailaja Elchuri, PhD
Department of Nanobiotechnology
Vision Research Foundation,
41/18 College Road, Nungambakkam
Chennai – 600 006.
Ph: +91-(044) 28271616 Extn:1358
Email: sailaja.elchuri@gmail.com